Mitochondria play a central role in energy metabolism within the cell. Mitochondrial dysfunctions lead to various neurodegenerative disorders and to the so-called "mitochondrial diseases". A vast amount of evidence points to the implication of mitochondria in such complex processes as apoptosis and cardioprotection. The purpose of this review is to present a recent state of our knowledge and understanding of the action of various therapeutically applied substances on mitochondria. These include antitumor, immunosuppressant, and antiviral drugs, potassium channel openers, sulfonylureas, and anesthetics. Some of these substances are specifically designed to affect mitochondrial functions. In other cases, drugs with primary targets in other cellular locations may modify mitochondrial functions as side effects. In any case, identification of mitochondria as primary or secondary targets of a drug may help us to better understand the drug's mechanism of action and open new perspectives for its application. As far as possible, the molecular mechanisms of the interference of particular drugs in the mitochondrial metabolism will be described. In some cases, metabolic routes in which the drugs interfere will also be briefly outlined.

中文翻译：

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线粒体作为药理学目标。

线粒体在细胞内的能量代谢中起着核心作用。线粒体功能障碍导致各种神经退行性疾病，并导致所谓的“线粒体疾病”。大量证据表明线粒体在细胞凋亡和心脏保护等复杂过程中的作用。这篇综述的目的是介绍我们对各种治疗性应用物质对线粒体作用的最新知识和了解。这些药物包括抗肿瘤药，免疫抑制剂和抗病毒药，钾通道开放剂，磺酰脲类和麻醉药。这些物质中有一些是专门设计用来影响线粒体功能的。在其他情况下，在其他细胞位置具有主要靶标的药物可能会改变线粒体功能，从而产生副作用。任何状况之下，将线粒体鉴定为药物的主要或次要靶点可能有助于我们更好地了解药物的作用机理，并为药物的应用开辟新的前景。将尽可能描述特定药物干扰线粒体代谢的分子机制。在某些情况下，也会简要概述药物干扰的代谢途径。