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Pathways of straight and branched chain fatty acid catabolism in higher plants.
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2002-03-01 , DOI: 10.1016/s0163-7827(01)00022-4
Ian A Graham 1 , Peter J Eastmond
Affiliation  

Significant advances in our knowledge of fatty acid breakdown in plants have been made since the subject was last comprehensively reviewed in the early 1990s. Many of the genes encoding the enzymes of peroxisomal beta-oxidation of straight chain fatty acids have now been identified. Biochemical genetic approaches in the model plant, Arabidopsis thaliana, have been particularly useful not only in the identification and functional characterisation of genes involved in fatty acid beta-oxidation but also in establishing the role of beta-oxidation at different stages in plant development. Advances in our understanding of branched chain amino acid catabolism have provided convincing evidence that mitochondria play an important role in this process. This work is discussed in the context of the long running debate on the sub-cellular localisation of fatty acid beta-oxidation in plants. A significant aspect of this review is that it provides the opportunity to present a comprehensive analysis of the complete Arabidopsis genome sequence for each of the different gene families that are known to be involved in beta-, alpha-, and omega-oxidation of fatty acids in plants. Inevitably, this increase in information, as well as providing many answers also raises many new intriguing questions, particularly as regards the regulation and physiological role of fatty acid catabolism throughout the higher plant life cycle.

中文翻译:

高等植物中直链和支链脂肪酸分解代谢的途径。

自 1990 年代初对该主题进行最后一次全面审查以来,我们对植物中脂肪酸分解的了解取得了重大进展。许多编码直链脂肪酸的过氧化物酶体β-氧化酶的基因现已被鉴定。模型植物拟南芥中的生化遗传方法不仅在脂肪酸 β-氧化相关基因的鉴定和功能表征方面特别有用,而且在确定 β-氧化在植物发育不同阶段的作用方面也特别有用。我们对支链氨基酸分解代谢的理解取得的进展提供了令人信服的证据,证明线粒体在这一过程中起着重要作用。这项工作是在关于植物中脂肪酸 β 氧化的亚细胞定位的长期争论的背景下讨论的。这篇综述的一个重要方面是,它提供了对已知参与脂肪酸 β-、α- 和 omega-氧化的每个不同基因家族的完整拟南芥基因组序列进行全面分析的机会在植物中。不可避免地,这种信息的增加以及提供许多答案也提出了许多有趣的新问题,特别是关于脂肪酸分解代谢在整个高等植物生命周期中的调节和生理作用。这篇综述的一个重要方面是,它提供了对已知参与脂肪酸 β-、α- 和 omega-氧化的每个不同基因家族的完整拟南芥基因组序列进行综合分析的机会在植物中。不可避免地,这种信息的增加以及提供许多答案也提出了许多有趣的新问题,特别是关于脂肪酸分解代谢在整个高等植物生命周期中的调节和生理作用。这篇综述的一个重要方面是,它提供了对已知参与脂肪酸 β-、α- 和 omega-氧化的每个不同基因家族的完整拟南芥基因组序列进行综合分析的机会在植物中。不可避免地,这种信息的增加以及提供许多答案也提出了许多有趣的新问题,特别是关于脂肪酸分解代谢在整个高等植物生命周期中的调节和生理作用。
更新日期:2019-11-01
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