Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B, the most widely used iron chelator in haematology over the past 30 years, has a major disadvantage of being orally inactive. Consequently, the successful design of an orally active, nontoxic, selective iron chelator has become a much sought after goal. In order to identify an ideal iron chelator for clinical use, a range of specifications must be considered such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. A wide range of chelator types bind iron(III) and of these, hexa-, tri-, and bidentate are capable of providing iron(III) with the favoured octahedral environment. In this review, the comparative properties of such ligands are discussed, examples being selected from hydroxamates, aminocarboxylates, hydroxypyridinones, orthosubstituted phenols and triazoles.

中文翻译：

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临床上有用的铁（III）选择性螯合剂的设计。

铁过载是一种严重的临床状况，可以通过使用铁特异性螯合剂来很大程度上预防。过去30年来，血液中使用最广泛的铁螯合剂Desferrioxamine-B具有口服失活的主要缺点。因此，成功设计口服活性，无毒，选择性的铁螯合剂已成为人们追求的目标。为了确定临床上理想的铁螯合剂，必须考虑一系列规格，例如金属选择性和亲和力，配合物的动力学稳定性，生物利用度和毒性。多种螯合剂类型结合铁（III），其中六，三和双齿能为铁（III）提供有利的八面体环境。在这篇综述中，讨论了这类配体的比较性质，