OBJECTIVES Patient-reported outcomes such as quality of life are gaining importance in the assessment of patients suffering from inflammatory bowel disease (IBD). The association of objectively measured physical activity and quality of life in patients with IBD has not been studied in depth. To investigate the association of disease-specific quality of life and physical activity as well as clinical and biochemical disease activity in patients with IBD. METHODS A total of 91 patients with IBD were stratified into 4 groups (Crohn's disease and ulcerative colitis, in remission and with moderate-severe activity, respectively) and evaluated in terms of disease-specific quality of life (Inflammatory Bowel Disease Questionnaire [IBDQ]), physical activity (accelerometry), body composition (bioelectrical impedance analysis), as well as clinical (Harvey-Bradshaw Index and Simple Clinical Colitis Activity Index) and biochemical (C-reactive protein and fecal calprotectin) parameters of disease activity. RESULTS In patients with moderate-severe disease activity, the IBDQ was significantly lower as compared to patients in remission (Mann-Whitney U test and Kruskal-Wallis test, P < 0.001). The physical activity level was higher in remission than in active disease (Mann-Whitney U test, P < 0.05). The IBDQ was significantly correlated with the duration of strenuous physical activity per day (P = 0.029178, r = 0.235), skeletal muscle mass (P = 0.033829, r = 0.229), and biomarkers of inflammation (C-reactive protein: P < 0.005, r = -0.335 and fecal calprotectin: P < 0.005, r = -0.385). DISCUSSION In this prospective, cross-sectional study, disease-specific quality of life was significantly associated with accelerometrically determined physical activity and disease activity in patients with IBD. This may be related to a reciprocal impact of these factors (DRKS00011370).

中文翻译：

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炎症性肠病患者的生活质量与基于可穿戴设备的身体活动相关：一项前瞻性观察性研究。


目标 患者报告的结果（例如生活质量）在评估炎症性肠病 (IBD) 患者时变得越来越重要。客观测量的体力活动与 IBD 患者生活质量之间的关系尚未得到深入研究。调查 IBD 患者疾病特异性生活质量和体力活动以及临床和生化疾病活动的关联。方法 总共 91 名 IBD 患者被分为 4 组（克罗恩病和溃疡性结肠炎，分别处于缓解期和中重度活动期），并根据疾病特异性生活质量进行评估（炎症性肠病问卷 [IBDQ]） ）、体力活动（加速度测量）、身体成分（生物电阻抗分析）以及疾病活动的临床（Harvey-Bradshaw 指数和简单临床结肠炎活动指数）和生化（C 反应蛋白和粪便钙卫蛋白）参数。结果 中重度疾病活动性患者的 IBDQ 显着低于缓解期患者（Mann-Whitney U 检验和 Kruskal-Wallis 检验，P < 0.001）。缓解期体力活动水平高于疾病活动期（Mann-Whitney U 检验，P < 0.05）。 IBDQ 与每天剧烈体力活动的持续时间（P = 0.029178，r = 0.235）、骨骼肌质量（P = 0.033829，r = 0.229）和炎症生物标志物（C 反应蛋白：P < 0.005）显着相关，r = -0.335 和粪便钙卫蛋白：P < 0.005，r = -0.385）。 讨论 在这项前瞻性横断面研究中，IBD 患者的疾病特异性生活质量与加速测定的体力活动和疾病活动显着相关。这可能与这些因素的相互影响有关（DRKS00011370）。