The purpose of this study was to investigate the permeation of the glycol ethers, 2-ethoxyethanol (2-EE) and 2-butoxyethanol (2-BE) through disposable, nitrile exam gloves using a modified American Society for Testing and Materials (ASTM) closed-loop module. The purple unsupported, unlined, powderless nitrile glove from Kimberly-Clark was challenged by the two pure glycol ethers. Their permeation parameters were measured with the aid of a 2.54 cm ASTM F739 closed-loop permeation cell using water collection at 35.0 ± 0.5°C in a moving tray water bath, and capillary gas chromatography-mass spectrometry for quantification. Each set of experiments consisted of four standard permeation cells with water as the collection solvent. The steady state permeation rate for 2-EE of 4.83 ± 0.45 µg/cm2/min was about 4 times that of 2-BE (1.27 ± 0.11 µg/cm2/min). Permeation of the more nonpolar 2-BE was less than for 2-EE. Both solvents exceeded the ASTM threshold normalized breakthrough time in the closed-loop testing module. Glove samples failed to pass permeation criteria defined by Kimberly Clark and Ansell. Such gloves are not recommended as personal protective equipment for exposure to 2-butoxyethanol or 2-ethoxyethanol, even for very short period exposures. Glove manufacturers should reconsider existing permeation testing method for low volatile compounds and apply the closed-loop module due to higher sensitivity and accuracy.

中文翻译：

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通过一次性丁腈手套渗透乙氧基和丁氧基乙醇。

这项研究的目的是使用改良的美国材料试验学会（ASTM）通过一次性腈检验手套研究乙二醇醚，2-乙氧基乙醇（2-EE）和2-丁氧基乙醇（2-BE）的渗透性闭环模块。金伯利-克拉克（Kimberly-Clark）的紫色无支撑，无衬里，无粉丁腈手套受到两种纯乙二醇醚的挑战。借助于2.54 cm ASTM F739闭环渗透池，使用移动托盘水浴中35.0±0.5°C的水收集，并通过毛细管气相色谱-质谱法进行定量，测量其渗透参数。每组实验由四个以水为收集溶剂的标准渗透池组成。2-EE的稳态渗透率为4.83±0.45 µg / cm2 / min，约为2-BE（1.27±0.11 µg / cm2 / min）的4倍。非极性2-BE的渗透小于2-EE。在闭环测试模块中，两种溶剂均超过了ASTM阈值标准化突破时间。手套样品未通过Kimberly Clark和Ansell定义的渗透标准。不建议将这种手套用作个人防护设备，即使暴露在非常短的时间内也要暴露于2-丁氧基乙醇或2-乙氧基乙醇。手套制造商应重新考虑现有的低挥发性化合物渗透测试方法，并应采用闭环模块，因为其灵敏度和准确性更高。不建议将这种手套用作个人防护设备，即使暴露在非常短的时间内也要暴露于2-丁氧基乙醇或2-乙氧基乙醇。手套制造商应重新考虑现有的低挥发性化合物渗透测试方法，并应采用闭环模块，因为其灵敏度和准确性更高。不建议将这种手套用作个人防护设备，即使暴露在非常短的时间内也要暴露于2-丁氧基乙醇或2-乙氧基乙醇。手套制造商应重新考虑现有的低挥发性化合物渗透测试方法，并应采用闭环模块，因为其灵敏度和准确性更高。