BACKGROUND We investigated the efficacy of electroconvulsive therapy in patients with major depressive disorder and concomitant anxiety symptoms and explored the relationships between depression symptoms and anxiety symptoms during acute electroconvulsive therapy. METHODS Major depressive disorder inpatients (N = 130) requiring electroconvulsive therapy were recruited for a maximum of 12 treatments each. Depression symptoms, using the core factor subscale derived from the 17-item Hamilton Depression Rating Scale, and anxiety symptoms, using the anxiety/somatization subscale from the Hamilton Depression Rating Scale-17, were assessed before electroconvulsive therapy, after every 3 electroconvulsive therapy treatments, and after the final electroconvulsive therapy. Both core factor subscale and anxiety/somatization subscale scores were converted to T-score units to compare the degrees of changes between depression symptoms and anxiety symptoms after electroconvulsive therapy. The relationships between core factor subscale and anxiety/somatization subscale were analyzed using the cross-lagged longitudinal model during acute electroconvulsive therapy. RESULTS A total 116 patients who completed at least the first 3 electroconvulsive therapy treatments were included in the analysis. Reduction of core factor scale T-scores was significantly greater than that of anxiety/somatization subscale T-scores. The model satisfied all indices of goodness-of-fit (chi-square = 30.204, df = 24, P = 0.178, Tucker-Lewis Index = 0.976, Comparative Fit Index = 0.989, Root Mean Square Error of Approximation = 0.047). Core factor subscale changes did not definitely predict subsequent anxiety/somatization subscale changes. CONCLUSIONS Electroconvulsive therapy is effective in the acute treatment of major depressive disorder patients associated with anxiety symptoms. Anxiety symptoms improved less than depression symptoms during acute electroconvulsive therapy. However, earlier reduction in depression symptoms does not definitely drive subsequent relief in anxiety symptoms.

中文翻译：

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重度抑郁症患者急性ECT期间抑郁症状与焦虑症状之间的关系。

背景技术我们研究了电痉挛疗法对重度抑郁症和伴发焦虑症状的患者的疗效，并探讨了急性电惊厥疗法期间抑郁症状与焦虑症状之间的关系。方法招募需要电抽搐治疗的重度抑郁症住院患者（N = 130），每人最多接受12种治疗。在抽搐治疗前，每3次电抽搐治疗后，评估使用从17个项的汉密尔顿抑郁评估量表得出的核心因子子量表的抑郁症状，并使用电击治疗前评估的汉密尔顿抑郁评估量表17中的焦虑/躯体化子量表的焦虑症状。 ，以及最后的电抽搐治疗后。将核心因子子量表和焦虑/躯体化子量表分数都转换为T分数单位，以比较电惊厥治疗后抑郁症状和焦虑症状之间的变化程度。急性电惊厥治疗过程中使用交叉滞后纵向模型分析了核心因素子量表与焦虑/躯体化子量表之间的关系。结果总共有116名患者至少完成了前3种电惊厥治疗。核心因素量表T分数的减少幅度明显大于焦虑/躯体化子量表T分数的减少幅度。该模型满足所有拟合优度指标（卡方= 30.204，df = 24，P = 0.178，塔克-刘易斯指数= 0.976，比较拟合指数= 0.989，近似均方根误差= 0.047）。核心因素分量表的变化并不能明确预测随后的焦虑/躯体化分量表的变化。结论电惊厥疗法可有效治疗伴有焦虑症状的重度抑郁症患者。在急性电惊厥治疗期间，焦虑症状的改善不及抑郁症状。但是，抑郁症状的早期减轻并不一定能驱使焦虑症状缓解。