BACKGROUND Marfan syndrome (MFS) is a genetic disorder of the connective tissue. It most prominently influences the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected as well. OBJECTIVE This study aims to investigate a realistic three-dimensional model of an aorta of a specific patient suffering from MFS by considering elastic and hyperelastic materials for the tissue using fluid-structure interaction (FSI). METHODS Isotropic linear elastic and Mooney-Rivlin hyperelastic assumptions are implemented. Linear and nonlinear mechanical properties of the aneurysmal MFS aortic tissue are derived from an uniaxial experimental test. RESULTS Vortex generation in the vicinity of the aneurysm region in both elastic and hyperelastic models and the maximum blood velocity at peak flow time is calculated as 0.517 and 0.533 m/s for the two materials, respectively. The blood pressure is not significantly different between the two models (±8 Pa) and the blood pressure difference between the points in the horizontal plane of the aneurysm region is obtained as ±10 Pa for both models. The maximum von Mises stress for the hyperelastic model (2.19 MPa) is 27% more than the elastic one (1.72 MPa) and takes place at the inner curvature and upper part of the aorta and somehow far from the aneurysm region. The wall shear stress (WSS) is also considered for the elastic and hyperelastic assumptions, which is 36.7 Pa for both elastic and hyperelastic models. CONCLUSION The aneurysm region in the MFS affects the blood flow and causes the vortex to be generated which consequently affects the blood flow in the downstream by adding some perturbations to the blood flow. The WSS is obtained to be lower in the aneurysm region compared to other regions which indicated vascular remodeling.

中文翻译：

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使用流体-结构相互作用，利用弹性和超弹性材料假设对Marfan综合征进行三维建模。

背景技术马凡氏综合症（MFS）是结缔组织的遗传疾病。它最显着地影响骨骼，心血管和眼部系统，但是整个身体的所有纤维结缔组织也会受到影响。目的本研究旨在通过使用流体-结构相互作用（FSI）考虑组织的弹性和超弹性材料，来研究患有MFS的特定患者主动脉的逼真的三维模型。方法实现各向同性线性弹性和Mooney-Rivlin超弹性假设。动脉瘤MFS主动脉组织的线性和非线性力学特性是从单轴实验测试得出的。结果在两种模型中，在弹性模型和超弹性模型中，在动脉瘤区域附近的涡流生成和峰值流速时的最大血流速度分别计算为0.517和0.533 m / s。两种模型之间的血压无明显差异（±8 Pa），两种模型的动脉瘤区域水平面内各点之间的血压差均为±10 Pa。超弹性模型的最大冯·米塞斯应力（2.19 MPa）比弹性模型（1.72 MPa）高27％，最大应力发生在主动脉的内曲率和上部，并远离动脉瘤区域。对于弹性和超弹性假设，还应考虑壁面剪应力（WSS），对于弹性和超弹性模型，其均为36.7 Pa。结论MFS中的动脉瘤区域会影响血流，并导致产生涡流，从而通过在血流中增加一些扰动而影响下游的血流。与表明血管重塑的其他区域相比，在动脉瘤区域中获得的WSS更低。