Vancomycin, teicoplanin, and ramoplanin are potent glycopeptide antibiotics that act by inhibiting bacterial cell wall biosynthesis. The former are used clinically as the antibiotics of last resort for the treatment of methicillin-resistant Staphylococcus aureus and the latter is a promising new antibiotic that is not susceptible to the emerging bacterial resistance to vancomycin and teicoplanin. A summary of our recent total synthesis of the vancomycin aglycon, our first and second generation total syntheses of the teicoplanin aglycon, and our progress on the total synthesis of the ramoplanins is presented. This work lays the foundation for ongoing structure-function studies on the antibiotics that may clarify or define their site and mechanism of action leading to the development of improved or reengineered antibiotics.

中文翻译：

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万古霉素，替考拉宁和雷莫拉宁：合成和机制研究。

万古霉素，替考拉宁和雷莫拉宁是有效的糖肽抗生素，可通过抑制细菌细胞壁的生物合成起作用。前者在临床上用作治疗耐甲氧西林金黄色葡萄球菌的最后手段，后者是一种有前途的新抗生素，对新出现的对万古霉素和替考拉宁的细菌耐药性不敏感。介绍了我们最近对万古霉素糖苷配基的全合成，对替考拉宁糖苷配基的第一代和第二代全合成以及对雷莫拉汀的全合成的研究进展。这项工作为正在进行的对抗生素的结构功能研究奠定了基础，这些研究可以阐明或确定其位点和作用机理，从而开发出改良的或再造的抗生素。