The need for routine prolactin (PRL) measurement in the initial evaluation of erectile dysfunction (ED) has been questioned because of the low rate of hyperprolactinemia (HP) in these men and the costs involved. In addition, it is widely thought that sexual desire problems are a good clinical marker for HP and/or low testosterone in men with ED. Within a 15-month period, 844 consecutive PRL and sexual hormone determinations were conducted in men at the Kingston General Hospital. Of these patients, 138 were comprehensively evaluated at the first visit for ED and completed the International Index of Erectile Function (IIEF). In the 138 patients, 2.2% had severe hyperprolactinemia (>35 ng/ml), within the range of 1-5% previously reported. No correlation between initial prolactin value and the sexual desire domain or the erectile function domain (EFD) of the IIEF was found for this population. However, all cases of severe HP were found to occur in men who scored less than 10 in the EFD of the IIEF. Low libido is widely accepted as a marker of HP. In this study, HP was found in patients not reporting major problems with a desire disorder. Clinically significant HP may be reliably found with routine biochemical evaluation and in this series was not detected in patients with EFD scores above 10. A routine PRL measurement is inexpensive and early detection of a serious and treatable disease may afford greater therapeutic success.

中文翻译：

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严重的勃起功能障碍是高泌乳素血症的标志。

由于这些男性高泌乳素血症（HP）的发生率低且涉及成本高，因此在勃起功能障碍（ED）的初始评估中是否需要常规泌乳素（PRL）测量受到质疑。另外，广泛认为性欲问题是ED男性中HP和/或睾丸激素水平低的良好临床标志。在15个月内，金斯敦总医院对男性进行了844次连续PRL和性激素测定。在这些患者中，有138名在首次就诊时进行了综合评估，并完成了国际勃起功能指数（IIEF）。在138名患者中，有2.2％患有严重的高泌乳素血症（> 35 ng / ml），在先前报道的1-5％范围内。在该人群中，初始催乳素值与IIEF的性欲域或勃起功能域（EFD）之间没有相关性。但是，发现所有严重HP病例都发生在IIEF的EFD得分低于10的男性中。低性欲被广泛认为是HP的标志。在这项研究中，发现HP的患者未报告性欲障碍的主要问题。通过常规生化评估可以可靠地发现具有临床意义的HP，而在EFD评分高于10的患者中未检测到该系列HP。常规PRL测量价格便宜，并且早期发现严重可治疗的疾病可能会提供更大的治疗成功。低性欲被广泛认为是HP的标志。在这项研究中，发现HP的患者未报告性欲障碍的主要问题。通过常规的生化评估可以可靠地发现具有临床意义的HP，而在EFD得分高于10的患者中未检测到该系列HP。常规PRL测量价格低廉，早期发现严重可治疗的疾病可能会带来更大的治疗成功。低性欲被广泛认为是HP的标志。在这项研究中，发现HP的患者未报告性欲障碍的主要问题。通过常规生化评估可以可靠地发现具有临床意义的HP，而在EFD评分高于10的患者中未检测到该系列HP。常规PRL测量价格便宜，并且早期发现严重可治疗的疾病可能会提供更大的治疗成功。