The objective of this work was to determine the effectiveness of intracavernous injections (ICI) of vasoactive drugs in elderly men with erectile dysfunction and to compare the results obtained with the injection of two different drug combinations. It was a case control study. The sample consisted of 300 men, 63-85 y of age (mean 67.1) with erectile dysfunction of organic origin. Among the patients 180 underwent first trial with injection of prostaglandin E1 (PE). Further on these 180 patients and another 120 (in total 300 patients) were treated with a triple combination of papaverine hydrochlorate, phentolamine messylate and prostaglandin E1 (PPR). The number of responders to the injection of either PE alone or the drug combination was recorded. The quality of the erections was evaluated in the outpatient clinic by the medical staff and through patient's report after home trial. The average volume of either PE or PPR necessary to obtain a functional erection was measured. We observed a statistically significant association between the results obtained after the injection of PPR as compared to PE (chi2 with 2 d.f.: 34.666; P= < 0.001). A functional erection was obtained in 224/300 (74.7%) after the injection of PPR as compared to 87/180 men (48.3%) treated with PE. The average volume of PPR necessary to obtain a functional erection was 0.35+/-0.14 ml whereas that of PE was 1.3+/-0.3 ml. intracavernous injection of vasoactive drugs is still one of the most successful therapies for patients suffering from organic impotence. It is less effective in the older age group as compared to younger. However, if this form of therapy is chosen for aged men the triple combination therapy (PPR) yields a higher response rate than that obtained with prostaglandin alone.

中文翻译：

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腔内注射：仍然是治疗老年男性勃起功能障碍的金标准。

这项工作的目的是确定腔内注射血管活性药物在勃起功能障碍的老年男性中的有效性，并比较两种不同药物组合的注射结果。这是一个病例对照研究。样本包括300名年龄在63-85岁（平均67.1岁）且有器质性勃起功能障碍的男性。在这些患者中，有180名接受了前列腺素E1（PE）注射的首次试验。在这180名患者中，另外120名（总共300名患者）接受了盐酸罂粟碱，甲磺酸苯妥拉明和前列腺素E1（PPR）的三联治疗。记录对单独注射PE或药物组合的应答者的数量。勃起质量由医务人员在门诊诊所进行评估，并经过家庭试验后通过患者的报告进行评估。测量获得功能性勃起所需的PE或PPR的平均体积。我们观察到与PE相比，注射PPR后获得的结果之间具有统计学上的显着相关性（2 df的chi2：34.666； P = <0.001）。注射PPR后，在224/300（74.7％）处获得功能勃起，而用PE治疗的男性为87/180（48.3％）。获得功能性勃起所需的PPR平均体积为0.35 +/- 0.14 ml，而PE为1.3 +/- 0.3 ml。对于患有器质性阳ot的患者，腔内注射血管活性药物仍然是最成功的疗法之一。与年龄较小的人群相比，年龄较大的人群效果较差。但是，如果为老年男性选择这种治疗方式，则三联疗法（PPR）产生的应答率要高于单独使用前列腺素获得的应答率。