The anesthetized rabbit model is useful and has many advantages: ability to perform neurophysiological studies; more administration routes, including intracavernous injection; haemodynamic measurements in parallel to measurements of intracavernous pressure or penile volume; and direct measurement of intracavernosal pressure and blood flow. This model has been evaluated with many different types of drugs. The conscious rabbit model is a simple and valid model for the assessment of compounds with potential for treatment of ED. It offers several methodological advantages as a screening model for compounds with erection stimulating properties. It was clearly successful in demonstrating the efficacy and the mechanism of the new potent and selective PDE5 inhibitor vardenafil. The model was also effective in demonstrating erection-generating properties through other mechanisms, eg PDE3 inhibitors and alpha-receptor blockers. In conclusion, both anaesthetized rabbit model and the newly developed conscious-rabbit models are well-suited for studies in impotence research.

中文翻译：

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兔子作为阳imp研究的模型。

麻醉的兔子模型是有用的，并且具有许多优点：进行神经生理学研究的能力；更多的给药途径，包括海绵体内注射；血液动力学测量与海绵内压力或阴茎体积测量平行；并直接测量海绵体内的压力和血流量。已使用许多不同类型的药物对该模型进行了评估。有意识的兔子模型是用于评估具有治疗ED潜力的化合物的简单有效模型。作为具有勃起刺激特性的化合物的筛选模型，它具有多种方法学优势。在证明新型有效和选择性PDE5抑制剂伐地那非的功效和机理方面，它显然是成功的。该模型在通过其他机制（例如PDE3抑制剂和α受体阻滞剂）证明勃起产生特性方面也很有效。总之，麻醉的兔模型和新开发的自觉-兔子模型都非常适合阳imp研究。