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General use of animal models for investigation of the physiology of erection.
International Journal of Impotence Research ( IF 2.8 ) Pub Date : 2001-08-30 , DOI: 10.1038/sj.ijir.3900678
A L Burnett 1
Affiliation  

In review, animal models have accounted significantly for the amazing strides made in the field of sexual dysfunction research. Fundamentally, they have offered a unique experimental approach to test many hypotheses regarding sexual function. Since their early use for sexual physiology research, there has been increasing sophistication using animals involving techniques for stimulating and monitoring sexual responses. One specific area that has been advanced is the use of conscious animal models to obtain a better sense of the natural contexts for sexual physiology and to avoid pharmacological interference associated with anesthetics. Another area of interest is the increasing use of simple but valid techniques to record and assess sexual responses. Efforts to develop and evaluate animal models that replicate disorders of sexual function have also been most advantageous. In the future, animal models will remain useful. The expanded applications of animal models include the study of predisposing disease states associated with sexual dysfunction and the study of all aspects of sexual dysfunction, in both male and female subjects. Continued judgment must be applied, understanding the advantages of one or another animal model, to explore questions and provide answers that are most scientifically relevant to the human condition. The promise of advancing therapies in this field indicates the additional prominent role for animals for the purposes of drug development.

中文翻译:

一般使用动物模型来研究勃起生理。

综述中,动物模型在性功能障碍研究领域取得了惊人的进步。从根本上说,他们提供了一种独特的实验方法来检验有关性功能的许多假设。自从它们早期用于性生理研究以来,使用涉及刺激和监测性反应技术的动物的复杂性不断提高。已发展的一个特定领域是使用有意识的动物模型,以更好地了解性生理的自然环境,并避免与麻醉药相关的药理干扰。另一个有趣的领域是越来越多地使用简单但有效的技术来记录和评估性反应。开发和评估复制性功能障碍的动物模型的努力也是最有利的。将来,动物模型将仍然有用。动物模型的广泛应用包括在男性和女性受试者中研究与性功能障碍相关的易患疾病状态以及性功能障碍的各个方面。必须运用持续的判断力,了解一种或另一种动物模型的优势,以探索问题并提供与人类状况最科学相关的答案。在该领域中推进疗法的前景表明,在药物开发方面,动物还具有其他突出的作用。动物模型的广泛应用包括在男性和女性受试者中研究与性功能障碍相关的易患疾病状态以及性功能障碍的各个方面。必须运用持续的判断力,了解一种或另一种动物模型的优势,以探索问题并提供与人类状况最科学相关的答案。在该领域中推进疗法的前景表明,在药物开发方面,动物还具有其他突出的作用。动物模型的广泛应用包括在男性和女性受试者中研究与性功能障碍相关的易患疾病状态以及性功能障碍的各个方面。必须运用持续的判断力,了解一种或另一种动物模型的优势,以探索问题并提供与人类状况最科学相关的答案。在该领域中推进疗法的前景表明,在药物开发方面,动物还具有其他突出的作用。探索问题并提供与人类状况最科学相关的答案。在该领域中推进疗法的前景表明,在药物开发方面,动物还具有其他突出的作用。探索问题并提供与人类状况最科学相关的答案。在该领域中推进疗法的前景表明,在药物开发方面,动物还具有其他突出的作用。
更新日期:2019-11-01
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