The prophylactic effect of parentral administration of a single dose of Vitamin E-selenium preparation given to pregnant ewes during the last third of pregnancy for protection against nutritional muscular dystrophy (NMD) in their lambs was studied. Based on determination of serum muscle-specific enzymes in the lambs, it was found that administration of Vitamin E-selenium preparation to pregnant ewes from a flock with a known history of NMD was associated with a significant decrease in serum muscle-specific enzymes levels in their lambs when compared with those from non-treated dams in the same flock. It was also observed that serum muscle-specific enzyme levels in lambs from non-treated dams in the flock with a known history of NMD were significantly higher than those in lambs from non-treated dams in a flock with no history of NMD (control group). The serum creatine phosphokinase (CPK) level was significantly higher in lambs of treated dams as compared to lambs from the control group, but no significant differences were seen between the two groups of lambs for the other serum muscle-specific enzymes measured. No lambs from the treated group showed clinical signs of NMD up through the time of weaning. It is concluded that administration of Vitamin E-selenium preparation to pregnant ewes in a flock with a known history of NMD was effective in preventing NMD in their lambs.

中文翻译：

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沙特阿拉伯卡西姆地区营养性肌营养不良症的一些研究

研究了在怀孕的最后三分之一期间给怀孕的母羊肠胃外施用单剂量维生素 E-硒制剂的预防作用，以防止它们的羔羊发生营养性肌营养不良症 (NMD)。根据对羔羊血清肌肉特异性酶的测定，发现对已知有 NMD 病史的羊群中的妊娠母羊服用维生素 E-硒制剂可显着降低羔羊的血清肌肉特异性酶水平。将它们的羔羊与同一群中未经处理的母羊的羔羊进行比较。还观察到，已知有 NMD 病史的羊群中未经治疗的母羊羔羊的血清肌肉特异性酶水平显着高于没有 NMD 病史的羊群中未经治疗的母羊羔羊的血清肌肉特异性酶水平（对照组） ）。与对照组羔羊相比，处理组羔羊的血清肌酸磷酸激酶 (CPK) 水平显着更高，但两组羔羊之间测量的其他血清肌肉特异性酶没有显着差异。治疗组的羔羊在断奶期间没有表现出 NMD 的临床症状。结论是，在已知有 NMD 病史的羊群中，给怀孕的母羊服用维生素 E-硒制剂可有效预防羔羊的 NMD。治疗组的羔羊在断奶期间没有表现出 NMD 的临床症状。结论是，在已知有 NMD 病史的羊群中，给怀孕的母羊服用维生素 E-硒制剂可有效预防羔羊的 NMD。治疗组的羔羊在断奶期间没有表现出 NMD 的临床症状。结论是，在已知有 NMD 病史的羊群中，给怀孕的母羊服用维生素 E-硒制剂可有效预防羔羊的 NMD。