STUDY DESIGN A case report. OBJECTIVES To demonstrate stimulating action of F XIII in wound healing of complicated pressure sores. SETTING A Spinal Cord Injury Center in Germany. METHODS Clinical exam, clinical and photographic wound control, biochemical serum monitoring. RESULTS Recurrent pressure sores in plegic patients are common complications requiring long-standing conservative or operative therapy. Additional risk factors such as diabetes increase the complication rate for surgery. Surgery itself may be difficult in recurrent pressure sores due to limited remaining soft tissues. We report the case and treatment of a 47-year-old patient with long-standing and recurrent ulcers and complications after flap surgery. As a final option we added plasma transglutaminase (factor XIII) to our treatment scheme which changed the course of the disease dramatically and we achieved complete and rapid healing. CONCLUSION Our experience suggests that F XIII has a positive role in treating pressure sores as shown already in several other surgical fields. Its use is giving the surgeon an additional tool in complicated cases.

中文翻译：

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血浆转谷氨酰胺酶（F XIII）在脊髓损伤后复杂压疮伤口愈合中的作用。

研究设计病例报告。目的证明F XIII在复杂压疮伤口愈合中的刺激作用。在德国设立脊髓损伤中心。方法临床检查，临床和照相伤口控制，生化血清监测。结果复杂性患者的反复压疮是常见的并发症，需要长期的保守治疗或手术治疗。其他危险因素，例如糖尿病，增加了手术的并发症发生率。由于残留的软组织有限，手术本身在复发性压疮中可能很困难。我们报道了一名47岁的患者，该患者在皮瓣手术后具有长期复发性溃疡和并发症。作为最后的选择，我们在治疗方案中添加了血浆转谷氨酰胺酶（XIII因子），从而极大地改变了疾病的进程，并实现了完全而快速的康复。结论我们的经验表明，F XIII在治疗褥疮中具有积极作用，正如其他几个外科领域所显示的那样。它的使用为外科医生在复杂情况下提供了额外的工具。