OBJECTIVE To determine whether healthy males who consumed increased amounts of dietary stearic acid compared with increased dietary palmitic acid exhibited any changes in their platelet aggregability, platelet fatty acid profiles, platelet morphology, or haemostatic factors. DESIGN A randomized cross-over dietary intervention. SUBJECTS AND INTERVENTIONS Thirteen free-living healthy males consumed two experimental diets for 4 weeks with a 7 week washout between the two dietary periods. The diets consisted of approximately 30% of energy as fat (66% of which was the treatment fat) providing approximately 6.6% of energy as stearic acid (diet S) or approximately 7.8% of energy as palmitic acid (diet P). On days 0 and 28 of each dietary period, blood samples were collected and anthropometric and physiological measurements were recorded. RESULTS Stearic acid was increased significantly in platelet phospholipids on diet S (by 22%), while on diet P palmitic acid levels in platelet phospholipids also increased significantly (8%). Mean platelet volume, coagulation factor FVII activity and plasma lipid concentrations were significantly decreased on diet S, while platelet aggregation was significantly increased on diet P. CONCLUSION Results from this study indicate that stearic acid (19g/day) in the diet has beneficial effects on thrombogenic and atherogenic risk factors in males. The food industry might wish to consider the enrichment of foods with stearic acid in place of palmitic acid and trans fatty acids.

中文翻译：

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富含硬脂酸的饮食可改善健康男性的血栓形成和动脉粥样硬化危险因素。

目的确定健康男性摄入的饮食中硬脂酸的摄入量高于饮食中的棕榈酸的摄入量是否显示出血小板聚集性，血小板脂肪酸谱，血小板形态或止血因素的任何变化。设计随机交叉饮食干预。受试者和干预措施13名自由生活的健康男性在4个星期内进食了两种实验饮食，两次饮食之间的冲洗时间为7周。这些饮食包括大约30％的能量（脂肪）（其中66％是治疗用脂肪），提供大约6.6％的能量（如硬脂酸）（饮食S）或大约7.8％的能量（如棕榈酸）（饮食P）。在每个饮食期的第0天和第28天，采集血样并记录人体测量学和生理学测量值。结果饮食S的血小板磷脂中的硬脂酸显着增加（增加22％），而饮食P的血小板磷脂中的棕榈酸水平也显着增加（8％）。日粮S的平均血小板体积，凝血因子FVII活性和血浆脂质浓度显着降低，日粮P的血小板聚集显着增加。结论研究的结果表明日粮中的硬脂酸（19g /天）对日粮具有有益的作用。男性的血栓形成和动脉粥样硬化危险因素。食品工业可能希望考虑用硬脂酸代替棕榈酸和反式脂肪酸来丰富食品。日粮S的平均血小板体积，凝血因子FVII活性和血浆脂质浓度显着降低，日粮P的血小板聚集显着增加。结论研究的结果表明日粮中的硬脂酸（19g /天）对日粮具有有益的作用。男性的血栓形成和动脉粥样硬化危险因素。食品工业可能希望考虑用硬脂酸代替棕榈酸和反式脂肪酸来丰富食品。日粮S的平均血小板体积，凝血因子FVII活性和血浆脂质浓度显着降低，日粮P的血小板聚集显着增加。结论研究的结果表明日粮中的硬脂酸（19g /天）对日粮具有有益的作用。男性的血栓形成和动脉粥样硬化危险因素。食品工业可能希望考虑用硬脂酸代替棕榈酸和反式脂肪酸来丰富食品。