OBJECTIVE To evaluate childhood cancer in relation to duration of breast-feeding. SETTING Sweden. Records from Child Healthcare Centres were scrutinised regarding information on breast-feeding and other health-related items. SUBJECTS All children aged 0-14 y with a malignant disease (benign brain tumours included) during the time period 1988-91 (n = 962) were identified from the Swedish Cancer Register. An equal number of controls matched for sex and age were selected from the Swedish Birth Register. RESULTS Information was obtained for 835 cases and 860 controls. Overall, duration of breast-feeding did not influence the risk for a malignant disease in this age group. However, breast-feeding > or = 1 month increased the risk for non-Hodgkin's lymphoma (NHL) yielding an odds ratio (OR) 5.5 with 95% confidence interval (CI) 1.2-25. Breast-feeding 1 -< 6 months gave OR 5.1, CI 1.1-24 and > 6 months gave OR 7.0, CI 1.3-37 with a significant trend (P = 0.04). Adjustment for maternal and birth-related co-variates gave similar results. For other malignancies no significant changes of the risk were obtained. CONCLUSIONS Overall, no association between duration of breast-feeding and childhood malignancies was found except for a significantly increased risk for NHL, but this was based on low numbers of cases and needs to be confirmed in other investigations.

中文翻译：

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瑞典的母乳喂养时间和儿童恶性疾病的风险。

目的评估与母乳喂养时间有关的儿童期癌症。设置瑞典。检查了儿童保健中心的记录，以了解有关母乳喂养和其他与健康有关的物品的信息。研究对象从瑞典癌症登记处确定了所有在1988-91年（n = 962）期间患有恶性疾病（包括良性脑肿瘤）的0-14岁儿童。从瑞典出生登记册中选择了相同性别和年龄的对照。结果获得了835例病例和860例对照的信息。总体而言，在这个年龄段中，母乳喂养的持续时间不影响发生恶性疾病的风险。但是，母乳喂养>或= 1个月会增加非霍奇金淋巴瘤（NHL）的风险，比值比（OR）为5.5，95％置信区间（CI）为1.2-25。母乳喂养1-6个月的OR为5.1，CI为1.1-24，> 6个月的OR为7.0，CI 1.3-37，具有显着趋势（P = 0.04）。对产妇和与生育有关的协变量的调整得出了相似的结果。对于其他恶性肿瘤，未获得风险的重大变化。结论总体而言，除了显着增加NHL的风险外，未发现母乳喂养的持续时间与儿童恶性肿瘤之间存在关联，但这是基于低病例数，需要在其他研究中进行确认。