Based on their distinct characteristics, such as self-renewal and differentiation potential, human mesenchymal stem cells (hMSCs) have been proposed as a feasible tool for cancer therapy. The characteristic of hMSCs that can be used in cancer therapy is their ability to home to primary and metastatic tumor sites. Recent studies have shown that use of stem cells obtained from adult tissue may be a novel vehicle for stem cell-mediated cancer therapy with improved antitumor effects. Stem cells have been used as vehicles to deliver various agents to tumor sites in order to decrease the size of the tumor or increase the lifespan of the organism. Genetically modified MSCs have been shown to increase apoptosis and decrease growth and angiogenesis in solid tumors. In this review, we will focus on the potential of the genetically modified hMSC-based genetic therapy that is a combination of stem cell and gene therapy approaches and its potential advantages over current therapies.

中文翻译：

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将hMSCs编程为癌症的潜在遗传疗法。

基于它们的独特特征，例如自我更新和分化潜能，人间充质干细胞（hMSCs）已被提议作为癌症治疗的可行工具。可用于癌症治疗的hMSCs的特征是其能够归巢于原发性和转移性肿瘤部位。最近的研究表明，使用从成人组织获得的干细胞可能是一种具有改善的抗肿瘤作用的干细胞介导的癌症治疗新载体。干细胞已被用作将各种药剂递送至肿瘤部位的媒介物，以减小肿瘤的大小或增加生物体的寿命。基因修饰的MSC已显示可增加实体瘤中的细胞凋亡，并减少其生长和血管生成。在这篇评论中