Previous studies examining the association of leptin receptor (LEPR) Gln223Arg polymorphism with obstructive sleep apnea-hypopnea syndrome (OSAHS) risk have yielded controversial outcomes. We aimed to clarify whether LEPR Gln223Arg polymorphism was critically involved in the development of OSAHS. We thoroughly searched PubMed as well as CNKI datasets for collection of relevant studies, followed by analysis of odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk. However, subgroup analysis by Newcastle-Ottawa scale (NOS) scores revealed that, LEPR Gln223Arg polymorphism was significantly related to OSAHS risk in high-quality studies. In addition, we found no publication bias. Our findings suggest that LEPR Gln223Arg polymorphism might contribute to the risk of OSAHS. Well-designed studies with more subjects are needed for further validation of these results.

中文翻译：

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LEPR Gln223Arg 多态性与阻塞性睡眠呼吸暂停综合征的关联：荟萃分析。

先前研究瘦素受体 (LEPR) Gln223Arg 多态性与阻塞性睡眠呼吸暂停低通气综合征 (OSAHS) 风险之间的关联的研究产生了有争议的结果。我们旨在阐明 LEPR Gln223Arg 多态性是否与 OSAHS 的发展密切相关。我们彻底搜索了 PubMed 和 CNKI 数据集以收集相关研究，然后分析比值比 (OR) 和相应的 95% 置信区间 (CI)。在我们纳入的七项病例对照研究中，LEPR Gln223Arg 多态性与 OSAHS 风险之间的相关性不显着。然而，纽卡斯尔-渥太华量表 (NOS) 评分的亚组分析显示，在高质量研究中，LEPR Gln223Arg 多态性与 OSAHS 风险显着相关。此外，我们没有发现发表偏倚。我们的研究结果表明 LEPR Gln223Arg 多态性可能会增加 OSAHS 的风险。需要对更多受试者进行精心设计的研究以进一步验证这些结果。