Circular RNA, also called circRNA, is a type of widespread RNA that is mainly derived from the spliceosome, from which DNA is transcribed into messenger RNA (mRNA). CircRNAs are characterized by the formation of a covalently closed continuous loop, and they play a variety of gene regulatory roles. CircRNAs were initially thought to represent splicing errors, but an increasing amount of evidence indicates that they may play significant roles in a variety of human diseases, including cancers, cardiovascular disease, neurological disorders, and pre-eclampsia. Studies have suggested that circRNAs regulate miRNA activity that arises from miRNA-mediated sponge effects. It has been shown that CDR1as acts as a sponge for miR-7 and that a testis-specific circRNA within the sex-determining region of Y (SRY) acts as a sponge for miR-138. Because miR-7 and miR-138 modulate several oncogenes and tumor suppressor genes, the interactions between ciRS-7 and miR-7 and between SRY and miR-138 may play important roles in cancer-related pathways. Hence, currently available data suggest that circRNAs may exert significant effects on diagnoses, prognoses, and therapies in ovarian cancer.

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环形RNA在卵巢癌中是否具有重要作用？

环状RNA，也称为circRNA，是一种广泛分布的RNA，主要来源于剪接体，DNA从剪接体转录成信使RNA（mRNA）。CircRNA的特征是形成共价闭合的连续环，并且它们起着多种基因调节作用。最初认为CircRNA代表剪接错误，但是越来越多的证据表明CircRNA可能在多种人类疾病中发挥重要作用，包括癌症，心血管疾病，神经系统疾病和先兆子痫。研究表明，circRNA调节由miRNA介导的海绵效应产生的miRNA活性。已经显示，CDR1as充当miR-7的海绵，Y的性别决定区域（SRY）内的睾丸特异性circRNA充当miR-138的海绵。由于miR-7和miR-138调控几种癌基因和抑癌基因，因此ciRS-7和miR-7之间以及SRY和miR-138之间的相互作用可能在癌症相关途径中发挥重要作用。因此，目前可获得的数据表明，circRNAs可能对卵巢癌的诊断，预后和治疗产生重大影响。