Communication between the nervous and immune systems is required for the body to regulate physiological homeostasis. Beta-adrenergic receptors expressed on immune cells mediate the modulation of immune response by neural activity. Activation of beta-adrenergic signaling results in suppression of antitumor immune response and limits the efficacy of cancer immunotherapy. Beta-adrenergic signaling is also involved in regulation of hematopoietic reconstitution, which is critical to the graft-versus-tumor (GVT) effect and to graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT). In this review, the function of beta-adrenergic signaling in mediating tumor immunosuppression will be highlighted. We will also discuss the implication of targeting beta-adrenergic signaling to improve the efficacy of cancer immunotherapy including the GVT effect, and to diminish the adverse effects including GVHD.

中文翻译：

---

β-肾上腺素信号传导在肿瘤免疫学和免疫治疗中。

神经和免疫系统之间的通讯是身体调节生理稳态所必需的。免疫细胞上表达的β-肾上腺素能受体通过神经活动介导免疫反应的调节。β-肾上腺素信号传导的激活导致抗肿瘤免疫反应的抑制并限制了癌症免疫疗法的功效。β-肾上腺素信号也参与造血重建，这对于同种异体造血细胞移植（HCT）后的移植物抗肿瘤（GVT）效应和移植物抗宿主病（GVHD）至关重要。在这篇综述中，将突出β-肾上腺素能信号传导在介导肿瘤免疫抑制中的作用。