Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.

中文翻译：

---

抗菌肽 LL-37/CRAMP 在保护结肠微生物群平衡、粘膜稳态、抗炎反应和抗癌作用中的关键作用。


小鼠凯瑟琳相关抗菌肽 (CRAMP) 及其同源人凯瑟琳素 (LL-37) 在先天免疫反应、血管生成和伤口愈合中发挥着积极作用。此外，LL-37/CRAMP 可抵御微生物并防止结肠感染，因为结肠上皮暴露于多种肠道病原体。人们越来越认识到，LL-37/CRAMP 可以维持结肠粘膜屏障的完整性，塑造微生物群的组成，并保护宿主免受肿瘤发生。在这篇综述中，我们讨论了 LL-37/CRAMP 在宿主体内平衡中的重要性，来自 CRAMP 缺陷小鼠的新发现支持了这种天然抗菌肽和免疫调节剂作为治疗开发药物先导的主张。