Fibrinogen is an important coagulation factor that plays a key role in thrombus formation. The co-existence of CAD, insulin resistance (IR) and coagulation incongruity are believed to exacerbate the existing condition towards more lethal pathological events.The purpose of current study was to find out a possible association between fibrinogen and IR in CAD patients. The study population consist of 135 participants; 82 angiographically confirmed CAD patients who visited the outpatient department at King Abdulaziz University Hospital (KAUH), Jeddah and 53 healthy control individuals. Peripheral blood samples were collected from CAD patients and healthy control individuals. Various biochemical parameters such as complete blood count, C-reactive protein (CRP), glycosylated hemoglobin (HbA1c), insulin, C-peptide, lipid profile, platelet, partial thromboplastin time (PTT), fibrinogen and D-dimer levels were measured by the use of different analytical methods. Calculation of homeostasis model assessment (HOMA) and non-HDL were done by using online tools. Among the studied parameters, majority of the conventional risk factors were found to be significantly increased in CAD patients compared with control individuals. Different coagulation components such as fibrinogen (223.8 vs. 394 mg/dL), D-dimer (0.25 vs. 0.63 mg/L), platelet (222.9 vs. 245.9 K/uL) and PTT (27.6 vs. 29.6 seconds) were also found to be significantly enhanced in CAD patients. Based on the severity of IR [HOMA index up to 3 and ≥ 3], comparison with different parameters such as fibrinogen, D-dimer, C-peptide and insulin in CAD groups were also made. As per HOMA index, fibrinogen level was found to be significantly increased in below and above 3 categories. Moreover, C-peptide (P < 0.01) and insulin (P < 0.001) levels also showed significant association with both HOMA groups. Our study provides an insight towards the association of fibrinogen and IR in CAD patients with respect to severity.

中文翻译：

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血管造影确定的冠状动脉疾病患者血浆纤维蛋白原水平与胰岛素抵抗的关系。

纤维蛋白原是重要的凝血因子，在血栓形成中起关键作用。人们认为，CAD，胰岛素抵抗（IR）和凝血功能不全的并存会加剧现有状况，并导致更多的致死性病理事件。本研究的目的是找出CAD患者中纤维蛋白原与IR之间的可能联系。研究人群包括135名参与者。82例经血管造影确诊的CAD患者，吉达阿卜杜勒阿齐兹国王大学医院（KAUH）的门诊患者和53名健康对照者。从CAD患者和健康对照个体收集外周血样品。各种生化参数，例如全血细胞计数，C反应蛋白（CRP），糖基化血红蛋白（HbA1c），胰岛素，C肽，脂质分布，血小板，使用不同的分析方法测量部分凝血活酶时间（PTT），纤维蛋白原和D-二聚体水平。稳态模型评估（HOMA）和非HDL的计算是通过使用在线工具完成的。在研究的参数中，与对照组相比，CAD患者中大多数常规危险因素均显着增加。也有不同的凝血成分，例如纤维蛋白原（223.8 vs.394 mg / dL），D-二聚体（0.25 vs.0.63 mg / L），血小板（222.9 vs.245.9 K / uL）和PTT（27.6 vs.29.6秒）。发现在CAD患者中明显增强。根据IR的严重程度[HOMA指数高达3和≥3]，还与CAD组中的不同参数（如纤维蛋白原，D-二聚体，C-肽和胰岛素）进行了比较。根据HOMA索引，发现纤维蛋白原水平在以下三个类别中均显着增加。此外，C肽（P <0.01）和胰岛素（P <0.001）水平也显示出与两个HOMA组均显着相关。我们的研究针对严重程度对CAD患者中纤维蛋白原和IR的关系提供了见解。