We sought in this study to examine the effects of diurnal blood pressure variations upon common carotid artery (CCA) elasticity in selected subjects with uncomplicated moderate essential hypertension. Towards this end, 174 non-smoker subjects with stage I-II essential hypertension and without diabetes mellitus, left ventricular hypertrophy and carotid atherosclerosis, were classified as dippers and non-dippers according to the diurnal variation of >10% between mean daytime and night-time systolic and diastolic blood pressure (BP) in 24-h non-invasive ambulatory BP monitoring. CCA distensibility was derived by a combination of surface ultrasonographic data and simultaneous BP measurements at the brachial artery. The dippers and non-dippers were similar with respect to demographic characteristics. Non-dippers had significantly greater office systolic BP, 24-h systolic BP and ambulatory pulse pressure (PP) and significantly less (daytime-night-time) systolic and diastolic BP fall (by 16 mm Hg and 11 mm Hg respectively, P< 0.0001) compared to dippers. CCA distensibility was significantly reduced in non-dippers compared to dippers (by 0.89 dyne(-1)/cm(2/)10(-6), P < 0.05). Multiple linear regression analysis identified patient age and ambulatory PP as significant predictors of the CCA elasticity index. When patient age, 24-h systolic and diastolic BP were used as covariates in an analysis of covariance, the difference of CCA elasticity between dippers and non-dippers ceased to reach statistical significance. In contrast, when patient age, ambulatory PP, systolic (daytime-night-time) BP fall and diastolic (daytime-night-time) BP fall were used as covariates, the difference of CCA distensibility between dippers and non-dippers continued to be statistically significant. In conclusion, the excessive impairment of CCA elastic properties in non-dippers compared to dippers hypertensive seems to be ascribed to the increased of total 24-h haemodynamic load and not to the circadian pattern of BP. Journal of Human Hypertension (2000) 14, 813-818

中文翻译：

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在基本高血压受试者中，昼夜血压变化对颈动脉弹性特性没有任何显着影响。

在这项研究中，我们寻求检验每日血压变化对选定的患有简单中度原发性高血压的受试者的颈总动脉（CCA）弹性的影响。为此，根据平均昼夜之间的日变化> 10％，将174名I-II期原发性高血压，无糖尿病，左心室肥大和颈动脉粥样硬化的非吸烟者分为北斗星和非北斗星。 24小时无创动态血压监测中的实时收缩压和舒张压（BP）。CCA扩张性是通过表面超声数据和肱动脉同时BP测量的组合得出的。在人口统计学特征上，北斗和北斗相似。非北斗星的办公室收缩压，24小时收缩压和门诊脉搏压（PP）明显升高，收缩压和舒张压下降幅度（白天-夜间）显着减少（分别降低16 mm Hg和11 mm Hg，P < 0.0001），而不是北斗星。与浸入式浸胶相比，非浸入式浸润剂的CCA膨胀性显着降低（降低了0.89达因（-1）/ cm（2 /）10（-6），P <0.05）。多元线性回归分析确定了患者年龄和门诊PP是CCA弹性指数的重要预测指标。当患者年龄，24小时收缩压和舒张压被用作协变量进行协方差分析时，北斗与非北斗之间的CCA弹性差异不再达到统计学意义。相反，当患者年龄较大时，非卧床PP 收缩压（白天-夜间）BP下降和舒张压（白天-夜间）BP下降作为协变量，北斗七星和非北斗七星的CCA扩张度差异仍具有统计学意义。总而言之，与浸入式高血压相比，非浸入式CCA弹性性能的过度损害似乎归因于总的24小时血液动力学负荷增加，而不是BP的昼夜节律模式。人类高血压杂志（2000）14，813-818