PURPOSE Measuring quality of life in acute asthmatics is challenging, especially when asthma attacks can occur sporadically. Several questionnaires can be used to measure quality of life in this patient group; however, psychometric testing is limited on questionnaires that can be used to estimate Quality Adjusted Life years. The objective of this study is to assess the construct validity (convergent and discriminative validity) and responsiveness of the EuroQol-5-Dimensions 5-Level (EQ-5D-5L), Asthma Quality of Life Utility Index-5 Dimensions (AQL-5D) and Time Trade-Off (TTO) in acute asthma patients. METHODS Data from a prospective cohort study were used to test the validity and responsiveness of the EQ-5D-5L, AQL-5D and TTO in asthma patients who were recruited from UK accident & emergency departments or hospital wards. The spearman's rank correlation coefficient, the Kruskal-Wallis test statistic and the standardized response mean were used to test for convergent validity, discriminative validity and responsiveness, respectively. RESULTS One hundred and twenty-one participants were included in the available case analysis. The EQ-5D-5L and AQL-5D showed moderate to strong correlations for convergent validity at baseline, week 4 and week 8. The AQL-5D and TTO showed moderate correlations at week 4 and week 8. No statistical significance was observed for discriminative validity at baseline. Both the EQ-5D-5L and the AQL-5D also showed that they were sensitive to change for the recovery responses. CONCLUSIONS The EQ-5D-5L and AQL-5D showed stronger construct validity and responsiveness compared to the TTO. Therefore, both the EQ-5D-5L and AQL-5D should be considered for use in future economic evaluations.

中文翻译：

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EQ-5D-5L、AQL-5D 和定制 TTO 在急性哮喘患者中的结构有效性和反应性。

目的测量急性哮喘患者的生活质量具有挑战性，特别是当哮喘偶尔发作时。可以使用多种问卷来衡量该患者群体的生活质量；然而，心理测量测试仅限于可用于估计质量调整生命年的问卷。本研究的目的是评估 EuroQol-5 维度 5 级 (EQ-5D-5L)、哮喘生活质量效用指数 5 维度 (AQL-5D) 的结构效度（收敛效度和判别效度）和反应性）和急性哮喘患者的时间权衡（TTO）。方法 使用前瞻性队列研究的数据来测试 EQ-5D-5L、AQL-5D 和 TTO 在从英国急症室或医院病房招募的哮喘患者中的有效性和反应性。分别使用斯皮尔曼等级相关系数、Kruskal-Wallis 检验统计量和标准化响应均值来检验收敛效度、区分效度和响应性。结果 现有案例分析中纳入了 121 名参与者。EQ-5D-5L 和 AQL-5D 在基线、第 4 周和第 8 周显示出收敛效度的中度至强相关性。AQL-5D 和 TTO 在第 4 周和第 8 周显示出中度相关性。没有观察到区分性的统计显着性。基线的有效性。EQ-5D-5L 和 AQL-5D 也表明它们对恢复反应的变化很敏感。结论 与 TTO 相比，EQ-5D-5L 和 AQL-5D 显示出更强的结构效度和响应性。因此，在未来的经济评估中应考虑使用EQ-5D-5L和AQL-5D。