Protein-protein interactions involving β-sheet secondary structures have been questioned in many fatal human diseases such as cancer, autoimmune and neurodegenerative diseases. Small selective peptide derivatives and analogues are promising drug candidates for inhibiting this poorly known class of PPIs. In this review, we will highlight the main strategies developed for designing linear and cyclic peptide and peptidomimetic inhibitors of PPIs involving β-sheet structures. These compounds either do not adopt preferred conformations or can mimic protein secondary structures such as β-strands, β-hairpins or α-helices.

中文翻译：

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肽和拟肽作为涉及β-sheet二级结构的蛋白质相互作用的抑制剂。

在许多致命的人类疾病（例如癌症，自身免疫性疾病和神经退行性疾病）中，涉及β-sheet二级结构的蛋白质-蛋白质相互作用受到质疑。小选择性肽衍生物和类似物是抑制这种鲜为人知的PPI类的有前途的候选药物。在这篇综述中，我们将重点介绍为设计涉及β-sheet结构的PPI的线性和环状肽和拟肽抑制剂而开发的主要策略。这些化合物要么不采用优选的构象，要么可以模仿蛋白质二级结构，例如β链，β发夹或α螺旋。