Familial adenomatous polyposis (FAP) is an autosomal dominant condition that predisposes to multiple malignancies, most commonly colorectal carcinoma, but has rarely been associated with lymphoma. We discuss one patient found to have Burkitt-like Lymphoma (BLL) with 11q aberration in the setting of previously undiagnosed FAP. We review the literature of FAP and associated malignancies and the provisional WHO classification of Burkitt-like lymphoma with 11q aberration. Both FAP and Burkitt-like lymphoma with 11q aberration involve perturbation of the MYC network and this may provide insight into a connection between these two diagnoses. However, further study is needed to elucidate if there is an increased risk of BLL and other subtypes of lymphoma among patients with FAP in order to provide optimal counseling and surveillance for patients with FAP.

家族性腺瘤性息肉病 (FAP) 是一种常染色体显性遗传病，易患多种恶性肿瘤，最常见的是结直肠癌，但很少与淋巴瘤相关。我们讨论了一名在先前未确诊 FAP 的情况下发现具有 11q 畸变的伯基特样淋巴瘤 (BLL) 的患者。我们回顾了 FAP 和相关恶性肿瘤的文献，以及具有 11q 畸变的 Burkitt 样淋巴瘤的 WHO 临时分类。FAP 和具有 11q 畸变的 Burkitt 样淋巴瘤都涉及 MYC 网络的扰动，这可能有助于深入了解这两种诊断之间的联系。然而，需要进一步研究来阐明 FAP 患者中 BLL 和其他亚型淋巴瘤的风险是否增加，以便为 FAP 患者提供最佳咨询和监测。