As bioinert material, silicone has to be modified to display suitable biological properties. Peptides are attractive additives for such a purpose. Most of the time, several steps are needed for the synthesis of the peptide-modified silicone: first the silicone surface is modified to display a reactive function, then a bifunctional spacer can be grafted, and finally, the peptide is attached on the reactive group. However, some other alternatives exist to reduce the number of steps, involving either the synthesis of modified silicones by copolymerization, or the use of silylated peptides. This review present the different pathways and the conjugation chemistries developed so far to afford peptide silicones conjugates.

中文翻译：

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有机硅接枝的生物活性肽及其应用。

作为生物惰性材料，必须对有机硅进行改性以显示合适的生物学特性。肽是用于此目的的有吸引力的添加剂。在大多数情况下，肽修饰的有机硅的合成需要几个步骤：首先对有机硅表面进行修饰以显示反应性功能，然后可以接枝双功能间隔基，最后将肽连接到反应性基团上。然而，存在一些其他的选择来减少步骤的数量，包括通过共聚合成改性的硅氧烷或使用甲硅烷基化的肽。这项审查提出了不同的途径和迄今为止开发的共轭化学，以提供肽有机硅共轭物。