HLA gene expression has an important role in the autoimmune disease predisposition. We investigated the mRNA expression profile of the risk alleles HLA‐DRB1*15 and HLA‐DRB1*13 in a cohort of subjects both multiple sclerosis (MS) patients and healthy controls. Moreover, we explored the expression of the allele HLA‐DRB1*11 that is very frequent in our cohort from southern Italy. We found that the expression of MS‐associated alleles in heterozygous MS patients was always higher than the nonassociated alleles. The differential risk allele expression occurred also in nonaffected subjects, though with a lower increment compared to MS patients.

中文翻译：

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多发性硬化症的 HLA-DRB1 风险等位基因在意大利南部患者的血细胞中差异表达

HLA 基因表达在自身免疫性疾病的易感性中具有重要作用。我们研究了多发性硬化症 (MS) 患者和健康对照人群中风险等位基因 HLA-DRB1*15 和 HLA-DRB1*13 的 mRNA 表达谱。此外，我们探索了等位基因 HLA-DRB1*11 的表达，这在我们来自意大利南部的队列中非常常见。我们发现杂合 MS 患者中 MS 相关等位基因的表达总是高于非相关等位基因。差异风险等位基因表达也发生在未受影响的受试者中，但与 MS 患者相比增量较低。