This review provides an analysis of the role that membrane composition and structure plays in the resistance of microorganisms to antimicrobial peptides (AMPs). We describe the current models of membrane disruption caused by AMPs and the changes in the structural properties that microbial membranes undergo in response to AMPs. This is followed by an outline of how the phospholipid composition of microbial membranes contributes to the changes in membrane bilayer structure and how the composition can be analysed in significant detail by modern lipidomic techniques. Finally, we discuss the challenges to fully analyse microbial membrane composition and structure that may occur during the development of resistance to AMPs.

中文翻译：

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细菌脂质多样性和膜特性在调节抗菌肽活性和耐药性中的作用。

这篇综述分析了膜组成和结构在微生物对抗菌肽（AMPs）的抗性中的作用。我们描述了由AMPs引起的膜破坏的当前模型以及微生物膜响应AMPs所经历的结构特性的变化。随后概述微生物膜的磷脂成分如何促进膜双层结构的变化，以及如何通过现代脂质组学技术对组成进行详细分析。最后，我们讨论了全面分析可能对AMPs产生抗药性的微生物膜组成和结构的挑战。