A defining feature of eukaryotic cells is the segregation of complex biochemical processes among different intracellular compartments. The protein targeting, translocation, and trafficking pathways that sustain compartmentalization must recognize a diverse range of clients via degenerate signals. This recognition is imperfect, resulting in polypeptides at incorrect cellular locations. Cells have evolved mechanisms to selectively recognize mislocalized proteins and triage them for degradation or rescue. These spatial quality control pathways maintain cellular protein homeostasis, become especially important during organelle stress, and might contribute to disease when they are impaired or overwhelmed.

中文翻译：

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健康和疾病中错误定位蛋白质的识别和降解。

真核细胞的一个定义特征是复杂的生化过程在不同细胞内隔室之间的分离。维持区室化的蛋白质靶向、易位和运输途径必须通过简并信号识别各种客户。这种识别是不完善的，导致多肽位于不正确的细胞位置。细胞已经进化出机制来选择性地识别错误定位的蛋白质并将它们分类以进行降解或拯救。这些空间质量控制途径维持细胞蛋白质稳态，在细胞器应激期间变得尤为重要，并且在它们受损或不堪重负时可能导致疾病。