Although the discovery of the prion protein (PrP) resulted from its co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer's and Parkinson's disease.

中文翻译：

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小鼠神经退行性疾病的传播和转基因。

尽管the病毒蛋白（PrP）的发现是由于它与叙利亚仓鼠的瘙痒病感染性共同纯化而产生的，但与转基因和转基因小鼠的合作证明对于理解不仅涉及由PrP错折叠，聚集引起的病毒疾病的基本过程至关重要。 ，并扩散到其他更常见的神经退行性脑疾病中。在这篇综述中，我们重点研究用于研究小鼠瘙痒病和相关的PrP错折叠疾病的方法和概念方法，以及这些方法如何使我们对包括阿尔茨海默氏症和帕金森氏症在内的相关疾病有了更深入的了解。