Human genomes hold a record of the evolutionary forces that have shaped our species. Advances in DNA sequencing, functional genomics, and population genetic modeling have deepened our understanding of human demographic history, natural selection, and many other long-studied topics. These advances have also revealed many previously underappreciated factors that influence the evolution of the human genome, including functional modifications to DNA and histones, conserved 3D topological chromatin domains, structural variation, and heterogeneous mutation patterns along the genome. Using evolutionary theory as a lens to study these phenomena will lead to significant breakthroughs in understanding what makes us human and why we get sick.

中文翻译：

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人类基因组的进化。

人类基因组记录了塑造我们物种的进化力。DNA测序，功能基因组学和种群遗传建模的进步，加深了我们对人类人口历史，自然选择以及许多其他长期研究的话题的理解。这些进展还揭示了许多先前未得到充分认识的因素，这些因素会影响人类基因组的进化，包括对DNA和组蛋白的功能修饰，保守的3D拓扑染色质结构域，结构变异以及沿基因组的异质突变模式。以进化论为视角来研究这些现象将在理解什么使我们成为人类以及为什么生病方面取得重大突破。