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Structural connectivity alterations in chronic and episodic migraine: A diffusion magnetic resonance imaging connectomics study.
Cephalalgia ( IF 5.0 ) Pub Date : 2019-11-01 , DOI: 10.1177/0333102419885392
Álvaro Planchuelo-Gómez 1 , David García-Azorín 2 , Ángel L Guerrero 2, 3 , Santiago Aja-Fernández 1 , Margarita Rodríguez 4 , Rodrigo de Luis-García 1
Affiliation  

OBJECTIVE To identify possible structural connectivity alterations in patients with episodic and chronic migraine using magnetic resonance imaging data. METHODS Fifty-four episodic migraine, 56 chronic migraine patients and 50 controls underwent T1-weighted and diffusion-weighted magnetic resonance imaging acquisitions. Number of streamlines (trajectories of estimated fiber-tracts), mean fractional anisotropy, axial diffusivity and radial diffusivity were the connectome measures. Correlation analysis between connectome measures and duration and frequency of migraine was performed. RESULTS Higher and lower number of streamlines were found in connections involving regions like the superior frontal gyrus when comparing episodic and chronic migraineurs with controls (p < .05 false discovery rate). Between the left caudal anterior cingulate and right superior frontal gyri, more streamlines were found in chronic compared to episodic migraine. Higher and lower fractional anisotropy, axial diffusivity, and radial diffusivity were found between migraine groups and controls in connections involving regions like the hippocampus. Lower radial diffusivity and axial diffusivity were found in chronic compared to episodic migraine in connections involving regions like the putamen. In chronic migraine, duration of migraine was positively correlated with fractional anisotropy and axial diffusivity. CONCLUSIONS Structural strengthening of connections involving subcortical regions associated with pain processing and weakening in connections involving cortical regions associated with hyperexcitability may coexist in migraine.

中文翻译:

慢性和发作性偏头痛的结构连接性改变:扩散磁共振成像连接学研究。

目的利用磁共振成像数据确定发作性和慢性偏头痛患者可能的结构连接性改变。方法对54例发作性偏头痛,56例慢性偏头痛患者和50例对照组进行了T1加权和弥散加权磁共振成像采集。流线数(估计纤维束的轨迹),平均分数各向异性,轴向扩散率和径向扩散率是连接体度量。进行了连接组指标与偏头痛持续时间和频率之间的相关性分析。结果当将偶发性和慢性偏头痛患者与对照组进行比较时,在涉及上额回等区域的连接中发现流线的数量越来越少(p <0.05假发现率)。与发作性偏头痛相比,慢性左左前扣带回与右上额回之间有更多流线型。在偏头痛组和对照组中,在涉及海马等区域的连接之间发现较高和较低的分数各向异性,轴向扩散率和径向扩散率。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮质下区域的连接结构增强,而与过度兴奋相关的皮质区域的连接结构减弱。与发作性偏头痛相比,在慢性病中发现了更多的流线型。在偏头痛组和对照组中,在涉及海马等区域的连接之间发现较高和较低的分数各向异性,轴向扩散率和径向扩散率。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮质下区域的连接结构增强,而与过度兴奋相关的皮质区域的连接结构减弱。与发作性偏头痛相比,在慢性病中发现了更多的流线型。在偏头痛组和对照组中,在涉及海马等区域的连接之间发现较高和较低的分数各向异性,轴向扩散率和径向扩散率。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮质下区域的连接结构增强,而与过度兴奋相关的皮质区域的连接结构减弱。偏头痛组与对照组之间在涉及海马等区域的连接中发现了轴向扩散性和径向扩散性。与偶发性偏头痛相比,在慢性区域,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮质下区域的连接结构增强,而与过度兴奋相关的皮质区域的连接结构减弱。偏头痛组与对照组之间在涉及海马等区域的连接中发现了轴向扩散性和径向扩散性。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮质下区域的连接结构增强,而与过度兴奋相关的皮质区域的连接结构减弱。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮层下区域的连接结构增强和与过度兴奋性相关的皮层区域的连接结构减弱。与偶发性偏头痛相比,在慢性区域中,涉及壳状核等区域的径向扩散性和轴向扩散性较低。在慢性偏头痛中,偏头痛的持续时间与分数各向异性和轴向扩散率呈正相关。结论偏头痛可能涉及到与疼痛处理相关的皮层下区域的连接的结构加强和与过度兴奋性相关的皮层区域的连接的减弱。
更新日期:2020-04-10
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