Atrial fibrillation (AF) is a serious and common complication following heart surgery. Cardiac surgery triggers inflammation in the heart and makes it susceptible to the incidence of AF. Therefore, anti-inflammatory drugs may reduce the rate of AF incidence in the post-surgery conditions. Immunosuppressant agents, steroidal anti-inflammatory drugs (corticosteroids), non-aspirin non-steroid anti-inflammatory drugs (NSAIDs), colchicine and omega-3 unsaturated fatty acids (n-3 UFA) are drugs with well-known anti-inflammatory properties. The efficacy, safety and other aspects of using these drugs in the prevention of post-operative AF (POAF) have been reviewed here. Studies evaluating the efficacy of colchicine have shown that it could be effective in the prevention of POAF. However, there is a need for additional studies to find a colchicine regimen with optimal efficacy and higher tolerability. The use of corticosteroids may also be of value based on the most of meta-analyses. In the case of n-3 polyunsaturated fatty acids and NSAIDs, current data fail to support their efficacy in POAF prevention. Moreover, perioperative administration of NSAIDs may be associated with some severe safety considerations. Immunosuppressant agents have not been used for the prevention of POAF. Further studies are needed to find the most effective strategy for POAF prevention with the least safety considerations and the highest health benefits.

中文翻译：

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抗炎药在预防术后房颤中的作用：文献综述。

心房颤动（AF）是心脏手术后的一种严重且常见的并发症。心脏外科手术会触发心脏发炎，使其容易患AF。因此，抗炎药可能会降低术后状况中房颤的发生率。免疫抑制剂，类固醇消炎药（皮质类固醇），非阿司匹林非类固醇消炎药（NSAIDs），秋水仙碱和omega-3不饱和脂肪酸（n-3 UFA）是具有众所周知消炎特性的药物。本文对使用这些药物预防术后房颤（POAF）的功效，安全性和其他方面进行了综述。评估秋水仙碱功效的研究表明，它可以有效预防POAF。然而，有必要进行其他研究以找到具有最佳疗效和更高耐受性的秋水仙碱治疗方案。根据大多数荟萃分析，使用皮质类固醇激素也可能有价值。对于n-3多不饱和脂肪酸和NSAID，目前的数据未能支持其预防POAF的功效。此外，围手术期给予NSAID可能与一些严重的安全考虑有关。免疫抑制剂尚未用于预防POAF。需要进行进一步的研究，以找到安全性最低，健康益处最高的最有效的POAF预防策略。当前数据未能支持其预防POAF的功效。此外，围手术期给予NSAID可能与一些严重的安全考虑有关。免疫抑制剂尚未用于预防POAF。需要进行进一步的研究，以找到安全性最低，健康益处最高的最有效的POAF预防策略。当前数据未能支持其预防POAF的功效。此外，围手术期给予NSAID可能与一些严重的安全考虑有关。免疫抑制剂尚未用于预防POAF。需要进行进一步的研究，以找到安全性最低，健康益处最高的最有效的POAF预防策略。