PURPOSE The aim of this study is to investigate the changes in the volume of individual thalamic nuclei in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). METHODS We enrolled 80 TLE patients with HS and 40 healthy controls. All of the subjects underwent 3D T1-weighted imaging. The hippocampus subfields and thalamic nuclei were segmented using the FreeSurfer program. We investigated volume changes in thalamic nuclei according to the HS side involved, and types or antiepileptic drug (AED) response compared with healthy controls. RESULTS Compared with healthy controls, patients with HS showed atrophy of thalamic nuclei involving right and left parafascicular nuclei. In the right HS, the atrophy of the right thalamic nucleus was more prominent than that of the left thalamic nucleus, whereas the reduction in the volume of left thalamic nuclei was more prominent in patients with left HS. The reduction in thalamic nuclear volumes was more prominent in HS type 1 (atrophy of both CA1 and CA4 regions) than in other HS types. The suprageniculate nuclear volumes were significantly increased in patients with drug-controlled epilepsy. CONCLUSIONS Our study demonstrates thalamic nuclear atrophy in TLE patients with HS. In addition, the atrophy of individual thalamic nuclei varied according to the HS side, the HS types, and the AED response. These findings suggest that the role of thalamic nuclei varied in TLE with HS subtypes and displayed varying degrees of vulnerability in the pathology networks associated with the hippocampus.

中文翻译：

---

诊断为颞叶癫痫和海马硬化的患者丘脑核的定量分析。

目的本研究的目的是研究颞叶癫痫（TLE）和海马硬化（HS）患者个体丘脑核容量的变化。方法我们招募了80名TLE的HS患者和40名健康对照。所有受试者均接受3D T1加权成像。使用FreeSurfer程序对海马亚区和丘脑核进行了细分。我们根据所涉及的HS端调查了丘脑核的体积变化，并与健康对照相比对类型或抗癫痫药（AED）进行了研究。结果与健康对照组相比，HS患者表现出丘脑核萎缩，累及左右束旁核。在右HS中，右丘脑核的萎缩比左丘脑核的萎缩更为明显，左HS患者左丘脑核体积减少更为明显。与其他HS类型相比，HS 1型（CA1和CA4区域均萎缩）丘脑核体积的减少更为明显。药物控制性癫痫患者的超上核细胞数量显着增加。结论我们的研究表明TLE合并HS的患者丘脑核萎缩。此外，单个丘脑核的萎缩因HS侧，HS类型和AED反应而异。这些发现表明，丘脑核在具有HS亚型的TLE中的作用不同，并且在与海马有关的病理网络中显示出不同程度的脆弱性。与其他HS类型相比，HS 1型（CA1和CA4区域均萎缩）丘脑核体积的减少更为明显。药物控制性癫痫患者的超上核细胞数量显着增加。结论我们的研究表明TLE合并HS的患者丘脑核萎缩。此外，单个丘脑核的萎缩因HS侧，HS类型和AED反应而异。这些发现表明，丘脑核在具有HS亚型的TLE中的作用不同，并且在与海马有关的病理网络中显示出不同程度的脆弱性。与其他HS类型相比，HS 1型（CA1和CA4区域均萎缩）丘脑核体积的减少更为明显。药物控制性癫痫患者的超上核细胞数量显着增加。结论我们的研究表明TLE合并HS的患者丘脑核萎缩。此外，单个丘脑核的萎缩因HS侧，HS类型和AED反应而异。这些发现表明，丘脑核在具有HS亚型的TLE中的作用不同，并且在与海马有关的病理网络中显示出不同程度的脆弱性。结论我们的研究表明TLE合并HS的患者丘脑核萎缩。此外，单个丘脑核的萎缩因HS侧，HS类型和AED反应而异。这些发现表明，丘脑核在具有HS亚型的TLE中的作用不同，并且在与海马有关的病理网络中显示出不同程度的脆弱性。结论我们的研究表明TLE合并HS的患者丘脑核萎缩。此外，单个丘脑核的萎缩因HS侧，HS类型和AED反应而异。这些发现表明，丘脑核在具有HS亚型的TLE中的作用不同，并且在与海马有关的病理网络中显示出不同程度的脆弱性。