Elastic liposomes consist of phospholipids andof surfactants,could be considered as promising nanotechnological platforms for skin drug delivery. The aim of the present study was the formation of elastic liposomes by thin film hydration method, using different phospholipids and surfactants, in order to determine the effect of the components on their physical characteristics and on theirphysical stability.Physical properties of elastic liposomes were evaluated using dynamic light scattering (DLS)method. The particle size at the day of their preparation, was ranged between small and large unilamellar vesicles (SUVs and LUVs), dependent on the hydrophilicity of the surfactant used, while their PDI (Poly Dispersity Index) value was close to zero, indicating monodispersed systems. Physical stability study involved the measure of particle size, as a quantifiable physical property, at selected times over a 30-days period, at storage conditions: i) 4 °C, ii) 25 °C, iii) 45 °C, suggested that refrigerated conditions promote physical stability, while high temperatures induce aggregation. According to the physical stability study elastic liposomes composed ofTween80 were found to bemore stable than those composed of Span80, at ambient conditions. The goal of our investigation was centered to the development and evaluation of a well know liposomal category i.e elastic liposomes, by modified their composition with common surfactants (i.e. Span and/or Tween), creating, a new liposomal class namely, elastic lipo-niosomes. To the best of knowledge this the first time that these hybrid vesicles appeared in the literature exhibiting the aforementioned category lipid/surfactants and molar ratios.

中文翻译：

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弹性脂质体的制备和物理化学表征：用于其设计的路线图库

弹性脂质体由磷脂和表面活性剂组成，可被认为是一种有前景的皮肤给药纳米技术平台。本研究的目的是通过薄膜水合法形成弹性脂质体，使用不同的磷脂和表面活性剂，以确定组分对其物理特性和物理稳定性的影响。弹性脂质体的物理特性评估使用动态光散射 (DLS) 方法。制备当天的粒径介于大小单层囊泡（SUV 和 LUV）之间，取决于所用表面活性剂的亲水性，而它们的 PDI（多分散指数）值接近于零，表明是单分散系统. 物理稳定性研究涉及粒度的测量，作为可量化的物理特性，在 30 天期间的选定时间，在储存条件：i) 4 °C，ii) 25 °C，iii) 45 °C，表明冷藏条件促进物理稳定性，而高温诱导聚合。根据物理稳定性研究，发现在环境条件下，由吐温 80 组成的弹性脂质体比由 Span80 组成的弹性脂质体更稳定。我们研究的目标集中在开发和评估众所周知的脂质体类别，即弹性脂质体，通过使用常见的表面活性剂（即 Span 和/或 Tween）修改它们的组成，创建一个新的脂质体类别，即弹性脂质体. 据了解，这是这些混合囊泡首次出现在文献中，展示了上述类别的脂质/表面活性剂和摩尔比。