Adult stem cells are undifferentiated cells that are found in many different tissues after development. They are responsible for regenerating and repairing tissues after injury, as well as replacing cells when needed. Adult stem cells maintain a delicate balance between self-renewal to prevent depletion of the stem cell pool and differentiation to continually replenish downstream lineages. The important role of mitochondria in generating energy, calcium storage and regulating cell death is well established. However, new research has linked mitochondria to stem cell maintenance and fate. In addition, efficient mitochondrial quality control is critical for stem cell homeostasis to ensure their long-term survival in tissues. In this review, we discuss the latest evidence linking mitochondrial function, remodeling and turnover via autophagy to regulation of adult stem cell self-renewal and differentiation.

成体干细胞是发育后在许多不同组织中发现的未分化细胞。它们负责在受伤后再生和修复组织，以及在需要时更换细胞。成体干细胞在自我更新以防止干细胞库耗尽和分化以不断补充下游谱系之间保持微妙的平衡。线粒体在产生能量、钙储存和调节细胞死亡方面的重要作用已得到公认。然而，新的研究将线粒体与干细胞的维持和命运联系起来。此外，有效的线粒体质量控制对于干细胞稳态至关重要，以确保它们在组织中的长期存活。在这篇综述中，我们讨论了与线粒体功能相关的最新证据，