Morin, a flavonoid isolated from various medicinal herbal plants, has an anti-inflammatory effect. This study aimed to elucidate the anticatabolic effects and cellular mechanism of morin against interleukin-1β (IL-1β) in rat primary chondrocytes. Morin at 10–100 μM did not affect the viability of rat primary chondrocytes. Treatment with morin for 21 days ameliorated the IL-1β-induced decrease in extracellular matrix. Furthermore, treatment with morin attenuated IL-1β-induced proteoglycan loss in the articular cartilage through suppression of catabolic factors, such as matrix metalloproteinases, inflammatory mediators, and pro-inflammatory cytokines. These data indicated that morin exerted anticatabolic effects that can prevent and reduce progressive degeneration of the articular cartilage, and thus may be a potential candidate treatment for osteoarthritis.

中文翻译：

---

Morin 通过对抗白细胞介素 1β 诱导的大鼠原代软骨细胞炎症的抗分解代谢作用

Morin 是一种从各种药用植物中分离出来的黄酮类化合物，具有抗炎作用。本研究旨在阐明桑椹素对大鼠原代软骨细胞中白细胞介素-1β (IL-1β) 的抗分解代谢作用和细胞机制。10–100 μM 的 Morin 不影响大鼠原代软骨细胞的活力。用 morin 治疗 21 天改善了 IL-1β 诱导的细胞外基质减少。此外，通过抑制分解代谢因子，如基质金属蛋白酶、炎症介质和促炎细胞因子，用桑椹素治疗减轻了 IL-1β 诱导的关节软骨中蛋白多糖的损失。这些数据表明，morin 具有抗分解代谢作用，可以预防和减少关节软骨的进行性退化，