Low‐intensity anti‐vascular ultrasound therapy is an effective means of disrupting the blood supply in the tumor microenvironment. Its diminished effect on the surrounding vasculature is thought to be due to higher blood flow rates outside the tumor that decreases the interaction time between the endothelial lining and the microbubbles, which transduce acoustic energy to thermal heat. However, investigating the effect of circulation rate on the response to low‐intensity ultrasound is complicated by the heterogeneity of the in vivo vascular microenvironment. Here, a 3D microfluidic model is used to directly interrogate the dynamics of ultrasound stimulation.

中文翻译：

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流体流速决定了微流模型中低强度抗血管超声治疗的功效。

低强度抗血管超声治疗是破坏肿瘤微环境中血液供应的有效手段。据认为，其对周围脉管系统的影响减弱是由于肿瘤外部较高的血流速度，从而减少了内皮细胞内层与微泡之间的相互作用时间，从而将声能转化为热能。然而，由于体内血管微环境的异质性，研究循环速率对低强度超声反应的影响变得复杂。在这里，使用3D微流体模型直接询问超声刺激的动力学。