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Mathematical expression of membrane potential based on Ling’s adsorption theory is approximately the same as the Goldman–Hodgkin–Katz equation
Journal of Biological Physics ( IF 1.8 ) Pub Date : 2018-11-03 , DOI: 10.1007/s10867-018-9512-9
Hirohisa Tamagawa 1
Affiliation  

The Goldman–Hodgkin–Katz equation (GHK equation), one of the most successful achievements of membrane theory in electrophysiology, can precisely predict the membrane potential. Its conceptual foundation lies in the idea that the transmembrane ion transport across the plasma membrane is responsible for the membrane potential generation. However, the potential virtually equivalent to the membrane potential is generated even across the impermeable membrane. In this work, I discus the membrane potential generation mechanism and find that the potential formula based on the long-dismissed Ling’s adsorption theory, which attributes the membrane potential generation to the mobile ion adsorption rather than the transmembrane ion transport, is the same as the GHK equation. Based on this finding, I derive a conclusion that the membrane potential is generated by the ion adsorption against the existing electrophysiological concept.

中文翻译:

基于 Ling 吸附理论的膜电位数学表达式与 Goldman-Hodgkin-Katz 方程大致相同

Goldman-Hodgkin-Katz方程(GHK方程)是电生理学中膜理论最成功的成果之一,可以精确预测膜电位。其概念基础在于跨质膜的跨膜离子传输负责产生膜电位的想法。然而,即使穿过不可渗透的膜,也会产生几乎等于膜电位的电位。在这项工作中,我讨论了膜电位的产生机制,发现基于长期被忽视的 Ling 吸附理论的电位公式,将膜电位的产生归因于移动离子吸附而不是跨膜离子传输,与GHK 方程。基于这一发现,
更新日期:2018-11-03
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