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Physical control of tissue morphogenesis across scales.
Current Opinion in Genetics & Development ( IF 3.7 ) Pub Date : 2018-11-06 , DOI: 10.1016/j.gde.2018.09.002
Georgina A Stooke-Vaughan 1 , Otger Campàs 2
Affiliation  

During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue morphogenesis originates at cellular and subcellular scales, but it is their emergent behavior at supracellular scales that guides morphogenetic events. In this review, we highlight the physical quantities that can be spatiotemporally tuned at supracellular scales to sculpt tissues and organs during embryonic development of animal species, and connect them to the cellular and molecular mechanisms controlling them.

中文翻译:

跨尺度的组织形态发生的物理控制。

在胚胎发生过程中,组织和器官逐渐形成其功能形态。虽然有关组织和器官形状的信息是遗传编码的,但3D空间中的胚胎结构雕刻最终是一个物理过程。参与组织形态发生的物理量的控制起源于细胞和亚细胞尺度,但引导它们发生形态的是细胞超尺度上它们的出现行为。在这篇综述中,我们着重介绍了在动物胚胎发育过程中可以在细胞上尺度上时空调节到雕刻组织和器官的物理量,并将它们与控制它们的细胞和分子机制联系起来。
更新日期:2018-11-01
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