The striking rise of obesity-related metabolic disorders has focused attention on adipocytes as critical mediators of disease phenotypes. To better understand the role played by excess adipose in metabolic dysfunction it is crucial to decipher the transcriptional underpinnings of the low-grade adipose inflammation characteristic of diseases such as type 2 diabetes. Through employing a comparative transcriptomics approach, we identified IRF1 as differentially regulated between primary and in vitro-derived genetically matched adipocytes. This suggests a role as a mediator of adipocyte inflammatory phenotypes, similar to its function in other tissues. Utilizing adipose-derived mesenchymal progenitors we subsequently demonstrated that expression of IRF1 in adipocytes indeed contributes to upregulation of inflammatory processes, both in vitro and in vivo. This highlights IRF1's relevance to obesity-related inflammation and the resultant metabolic dysregulation.

肥胖相关代谢紊乱的惊人崛起将注意力集中在作为疾病表型的关键介质的脂肪细胞上。为了更好地了解过量脂肪在代谢功能障碍中所起的作用，至关重要的是弄清诸如2型糖尿病等疾病的低度脂肪炎症特征的转录基础。通过采用比较转录组学的方法，我们确定IRF1是初级和体外遗传匹配的脂肪细胞之间的差异调节。这暗示着其作为脂肪细胞炎性表型的介质的作用，类似于其在其他组织中的功能。利用脂肪来源的间充质祖细胞，我们随后证明了IRF1的表达在体内和体外，脂肪细胞中的TNF-α确实有助于炎症过程的上调。这突显了IRF1与肥胖相关的炎症以及由此引起的代谢失调有关。