The vectorial secretion and absorption of fluid and solutes by epithelial cells is dependent on the polarized expression of membrane solute transporters and channels at the apical and basolateral membranes. The establishment and maintenance of this polarized expression of transporters and channels are affected by divers protein-trafficking complexes. Moreover, regulation of the magnitude of transport is often under control of physiological stimuli, again through the interaction of transporters and channels with protein-trafficking complexes. This review highlights the value in utilizing transporters and channels as cargo to characterize core trafficking machinery by which epithelial cells establish and maintain their polarized expression, and how this machinery regulates fluid and solute transport in response to physiological stimuli.

中文翻译：

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上皮细胞中膜运输复合物对转运蛋白和通道的调节。


上皮细胞对液体和溶质的矢量分泌和吸收取决于顶膜和基底外侧膜的膜溶质转运蛋白和通道的极化表达。转运蛋白和通道的这种极化表达的建立和维持受到多种蛋白质运输复合物的影响。此外，转运量的调节通常受到生理刺激的控制，同样是通过转运蛋白和通道与蛋白质转运复合物的相互作用。本综述强调了利用转运蛋白和通道作为货物来表征核心运输机制的价值，上皮细胞通过该机制建立和维持其极化表达，以及该机制如何响应生理刺激来调节液体和溶质运输。