Collective cell migration is paramount to morphogenesis and contributes to the pathogenesis of cancer. To migrate directionally and reach their site of destination, migrating cells must distinguish a front and a rear. In addition to polarizing individually, cell-cell interactions in collectively migrating cells give rise to a higher order of polarity, which allows them to move as a supracellular unit. Rather than just conferring adhesion, emerging evidence indicates that cadherin-based adherens junctions intrinsically polarize the cluster and relay mechanical signals to establish both intracellular and supracellular polarity. In this review, we discuss the various functions of adherens junctions in polarity of migrating cohorts.

中文翻译：

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做头还是尾巴：集体迁移中细胞和超细胞极性中的细胞间粘附。

集体细胞迁移对于形态发生至关重要，并有助于癌症的发病机理。为了定向迁移并到达目的地，迁移单元必须区分正面和背面。除了单独极化外，集体迁移的细胞中的细胞间相互作用还引起更高阶的极性，这使它们可以作为超细胞单位移动。不仅仅是赋予粘附，新兴证据表明，基于钙粘着蛋白的粘附连接本质上使簇极化并传递机械信号以建立细胞内和细胞上极性。在这篇综述中，我们讨论了在迁移人群的极性中粘附连接的各种功能。