The ability of structure-based design to control the shape and reactivity-the atomic-level chemistry-of an immunogen argues for it being one of the "most powerful" immunogen-design strategies. But antigenic reactivity is only one of the properties required to induce a protective immune response. Here, a multidimensional approach is used to exemplify the enabling role atomic-level information can play in the development of immunogens against three viral pathogens, respiratory syncytial virus, influenza A virus, and human immunodeficiency virus (HIV), which have resisted standard approaches to vaccine development. Overall, structure-based strategies incorporating B-cell ontogenies and viral evasion mechanisms appear exceptionally powerful.

中文翻译：

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最有效的免疫原设计疫苗策略是什么？结构生物学家的观点。


基于结构的设计控制免疫原的形状和反应性（原子级化学）的能力证明它是“最强大的”免疫原设计策略之一。但抗原反应性只是诱导保护性免疫反应所需的特性之一。这里，使用多维方法来举例说明原子级信息在针对三种病毒病原体（呼吸道合胞病毒、甲型流感病毒和人类免疫缺陷病毒（HIV））的免疫原开发中可以发挥的促进作用，这三种病毒病原体已经抵制了标准方法疫苗开发。总体而言，结合 B 细胞个体发育和病毒逃避机制的基于结构的策略似乎异常强大。