In this perspective article, we emphasize the combination of Surface-Enhanced Raman Spectroscopy (SERS) and Microfluidic devices. SERS approaches have been widely studied and used for multiple applications including trace molecules detection, in situ analysis of biological samples and monitoring or, all of them with good results, however still with limitations of the technique, for example regarding with improved precision and reproducibility. These implications can be overcome by microfluidic approaches. The resulting coupling Microfluidics - SERS (MF-SERS) has recently gained increasing attention by creating thundering opportunities for the analytical field. For this purpose, we introduce some of the strategies developed to implement SERS within microfluidic reactor along with a brief overview of the most recent MF-SERS applications for biology, health and environmental concerns. Eventually, we will discuss future research opportunities of such systems.

中文翻译：

---

微流控技术和表面增强拉曼光谱：新分析工具的完美匹配。

在这篇透视文章中，我们强调表面增强拉曼光谱（SERS）和微流体装置的结合。SERS方法已被广泛研究并用于多种应用，包括痕量分子检测，生物样品的原位分析和监测，或者所有方法都具有良好的结果，但是仍然存在技术局限性，例如在提高精度和可重复性方面。这些影响可以通过微流体方法克服。由此产生的耦合微流体-SERS（MF-SERS）最近通过为分析领域创造更多机遇而受到越来越多的关注。为此，我们介绍一些为在微流体反应器中实施SERS而开发的策略，并简要概述了MF-SERS在生物学中的最新应用，健康和环境问题。最终，我们将讨论此类系统的未来研究机会。