Electrospinning is a micrometric or nanometric scale fiber manufacturing technique with structural factors such as greater contact surface and pore size that allows the incorporation of biological agents in its structure, increasing their potential for medical applications. Due to the conditions required for the electrospinning process, such as high voltage, in the present work, the evaluation of the antimicrobial activity of schizophyllan-based membranes elaborated by electrospinning at 20 kV incorporated with Hamamelis virginiana was carried out against Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa. The schizophyllan production was 1.97 gL-1 from strain Schizophyllum commune ScIBL1. The conditions for the process were standardized for voltage, feed flow, and the distance from the injector to the collector. Membranes with smooth-edged fibers, diameter of 819 nm without the presence of beads were obtained. However, it was found that the membranes lost antimicrobial activity against all the microorganisms evaluated, whereas, bioassays showed that null toxicity was presented.

中文翻译：

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基于Schizophyllan-PVOH和金缕梅提取物的电纺膜：抗菌活性对医学的重要性。

电纺丝是一种具有微米级或纳米级纤维制造技术，具有诸如更大的接触表面和孔径之类的结构因素，从而允许在其结构中掺入生物制剂，从而增加了其在医疗领域的潜力。由于当前静电纺丝工艺所需的条件，例如高压，因此对掺入金缕梅的20 kV静电纺丝制备的裂殖酸基膜的抗菌活性进行了评估，该抗微生物活性是针对金黄色葡萄球菌，白色念珠菌的。和铜绿假单胞菌。菌株Schizophyllum comcune ScIBL1的Schizophyllan产量为1.97 gL-1。该过程的条件针对电压，进料流量以及从进样器到收集器的距离进行了标准化。获得了具有光滑边缘纤维的膜，其直径为819nm而没有珠子。但是，发现该膜对所有评估的微生物均失去了抗菌活性，而生物测定法表明没有毒性。