Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression by influencing various biological processes including proliferation, apoptosis, differentiation, and senescence. Accumulating evidence implicates lncRNAs in the maintenance of metabolic homeostasis; dysregulation of certain lncRNAs promotes the progression of metabolic disorders such as diabetes, obesity, and cardiovascular diseases. In this review, we discuss our understanding of lncRNAs implicated in metabolic control, focusing on in particular diseases arising from chronic inflammation, insulin resistance, and lipid homeostasis. We have analyzed lncRNAs and their molecular targets involved in the pathogenesis of chronic liver disease, diabetes, and obesity, and have discussed the rising interest in lncRNAs as diagnostic and therapeutic targets improving metabolic homeostasis. This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen.

中文翻译：

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长非编码RNA在代谢控制中的作用。

通过影响各种生物学过程（包括增殖，凋亡，分化和衰老），长非编码RNA（lncRNA）已成为基因表达的关键调节剂。越来越多的证据表明lncRNAs参与了代谢稳态的维持。某些lncRNA的失调促进了代谢性疾病的发展，例如糖尿病，肥胖症和心血管疾病。在这篇综述中，我们讨论了我们对参与代谢控制的lncRNA的理解，特别是针对由慢性炎症，胰岛素抵抗和脂质稳态引起的疾病。我们已经分析了与慢性肝病，糖尿病和肥胖症发病机理有关的lncRNA及其分子靶标，并讨论了人们对lncRNAs作为改善代谢稳态的诊断和治疗靶标的兴趣日益浓厚。本文是由Kotb Abdelmohsen编辑的名为“控制基因表达的ncRNA”的特刊的一部分。