In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent papers on the adapter protein UBXD7, including one by Bandau et al. in BMC Biology, suggest that rather than simply linking p97 to ubiquitylated proteins, this adapter may be essential to coordinate ubiquitylation and p97-mediated extraction of the proteasome substrate. These findings add to growing indications of richly diverse roles of adapters in p97-mediated signaling functions.

中文翻译：

---

p97 复合体作为信号整合中心。

在泛素-蛋白酶体系统中，泛素化蛋白质的一个子集需要 AAA+ ATPase p97（也称为 VCP 或 Cdc48）才能从膜或蛋白质复合物中提取，然后再传递到蛋白酶体进行降解。已知多种泛素衔接子将 p97 与其客户蛋白联系起来，但最近有两篇关于衔接子蛋白 UBXD7 的论文，包括 Bandau 等人的一篇论文。在 BMC Biology 中，建议该适配器不是简单地将 p97 与泛素化蛋白质连接起来，而是协调泛素化和 p97 介导的蛋白酶体底物提取所必需的。这些发现进一步表明适配器在 p97 介导的信号传导功能中具有丰富多样的作用。