The discovery of multiple selenoproteins has raised tantalizing questions about their role in maintaining normal cellular function. Unfortunately, many of these remain inadequately investigated. While they have a role in maintaining redox balance, other functions are becoming increasingly recognized. As the roles of these selenoproteins are further characterized, a better understanding of the true physiological significance of this trace element will arise. This knowledge will be essential in defining optimum intakes to achieve cellular homeostasis in order to optimize health, including a reduction in cancer, for diverse populations. Human variation in the response to selenium likely reflects significant interactions between the type and amounts of selenium consumed with the genome and a host of environmental factors including the totality of the diet, as discussed in this review.

中文翻译：

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硒蛋白与癌症预防。

多种硒蛋白的发现提出了有关其在维持正常细胞功能中的作用的诱人问题。不幸的是，其中许多仍未得到充分调查。尽管它们在维持氧化还原平衡方面发挥着作用，但其他功能也逐渐得到认可。随着这些硒蛋白的作用被进一步表征，对这种微量元素的真正生理意义的更好理解将出现。该知识对于定义最佳摄入量以实现细胞稳态以优化健康（包括减少癌症）针对不同人群的摄入至关重要。